193 S. : Ill., graph. Darst. ; 21 cm, kart.


Gutes Ex. - Englisch. - To maintain a proper milieu interieur, our body is faced to eliminate efficiently the useless or harmful ballast of foreign compounds incorporated daily. In order to enhance excretion of lipophilic xenobiotics, higher organisms have evolved a variety of metabolic reactions to produce more hydrophilic derivatives that are easily excreted by the kidneys. The liver is the central organ to fulfil this task, but other organs may share it, too. In doing so, the organism runs some risk, because reactive intermediates can be formed which may injure the cells where they arise, or - if sufficiently stable - some distant sensitive organs they reach while travelling through the body. Hence, metabolism and cell toxicity are closely connected. (Verlagstext) // INHALT : Preface ---- Theodorus P M Akerboom and Helmut Sies: ---- Interorgan Transport of Glutathione ---- and Glutathione S-Conjugates ---- Harald Schempp and Erich F Elstner: ---- Induction of Cataract Formation by Redox Processes ---- Heidi Foth: ---- Toxicological Aspects of Xenobiotic Metabolism in Lung ---- Elmar Richter: ---- Intestinal First-Pass Metabolism of Xenobiotics ---- Hermann G Kampffmeyer: ---- Absorption and Metabolism of Xenobiotics ---- by Skin of Rabbit Ears ---- G H Degen, E Wolz and D Wild: ---- Prostaglandin H Synthase Dependent Activation ---- of the Food-Borne Mutagen 2-Amino-3-methylimidazo[4,5-f] ---- quinoline (IQ) ---- Hans-Giinter Neumann: ---- The Role of Non-Genotoxic Effects ---- on Tissue-Specific Tumor Formation of Genotoxic Arylamines ---- Peter Hlavica and Michael Lehnerer: ---- Mechanistic Aspects of Cytochrome P-450-Catalyzed ---- Arylamine Bioactivation in the Liver ---- Renate Heilmair, Christian Klimm and Werner Lenk: ---- Cooxidation of N-Hydroxy-4-chloroacetanilide and Oxyhaemoglobin in vitro ---- (u.a.) ISBN 9783411169917