Sachgebiete

Beschreibung:

XIV; 377 S.; Abb., graph. Darst. Fadengehefteter Originalpappband.

Bemerkung:

Sehr gutes Ex. - Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas-over-exposure to ultraviolet light-is well known, effective treatment has remained challenging; The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these groundbreaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies. This benchmark book provides the most up-to-date information on the new breed of melanoma therapies. Composed of the works of major researchers and clinicians, this book offers new insights, novel approaches, and promising data for effective treatment planning. Illuminating the latest advances in the field, it is a solid resource for clinical oncologists, translational scientists, and basic cancer researchers. // Part I Advances in Melanoma Biology -- Molecular Targets and Subtypes in Melanoma -- Michael A Davies -- Melanoma Genomics, -- Mohammed Kashani-Sabet -- Predictive Biomarkers as a Guide to Future Therapy -- Selection in Melanoma -- Thomas F Gajewski -- Part II Signaling Molecules as Molecular Targets -- KIT as a Therapeutic Target for Melanoma -- Nageatte Ibrahim and F Stephen Hodi -- Targeted Inhibition of B-Raf -- Paul B Chapman and Keith Flaherty -- The Notch and ß-Catenin Pathways -- John T Lee and Meenhard Herlyn -- STAT3 and Src Signaling in Melanoma -- Maciej Kujawski, Gregory Cherryholmes, -- Saul J Priceman, and Hua Yu -- Targeting the mTOR, PI3K, and AKT Pathways -- in Melanoma -- Kim A Margolin -- Targeting Apoptotic Pathways in Melanoma -- Peter Hersey and Xu Dong Zhang Anti-Angiogenesis Therapy in Melanoma -- Daniel S Chen -- Part III Rational Immunotherapy Approaches in Melanoma -- Melanoma Antigens Recognized by T Lymphocytes -- Nicolas van Baren, Jean-Francois Baurain, -- Francis Brasseur, and Pierre G Coulie -- Melanoma Vaccines -- Pedro Romero and Daniel E Speiser -- Adoptive Cell Therapy for the Treatment -- of Metastatic Melanoma -- Jessica Ann Chacon, Patrick Hwu, and Laszlo G Radvanyi -- Anti-CTLA-4 Monoclonal Antibodies -- Arvin S Yang and Jedd D Wolchok -- Anti-PD-1 and Anti-B7-Hl/PD-Ll Monoclonal Antibodies -- Evan J Lipson, Janis M Taube, Lieping Chen, and Suzanne L Topalian -- Treatment of Melanoma with Agonist Immune -- Costimulatory Agents -- Andrew Weinberg, Robert H Vonderheide, -- and Mario Sznol -- Novel Cytokines for Immunotherapy of Melanoma -- Shailender Bhatia and John A Thompson -- Modulating the Tumor Microenvironment -- Carl E Ruby and Howard L Kaufman. ISBN 9781617794063