Sachgebiete

Beschreibung:

X; 375 S. Fadengehefteter Originalpappband.

Bemerkung:

Sehr gutes Ex. - This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses. // Part I Local Invasion -- Reactivation of Epithelial-Mesenchymal Transition -- in Invasive and Metastatic Cancer -- Michael D Amatangelo and Mark E Stearns -- Biomechanical ECM Switches and Tumor Metastasis -- Jacquelyn J Ames, Calvin PH Vary, and Peter C Brooks -- Moving Aggressively: S100A4 and Tumor Invasion -- Reniqua P House, Sarah C Garrett, and Anne R Bresnick -- Regulation of TGF-ß Signaling and Metastatic Progression -- by Tumor Microenvironments -- Michael K Wendt and William P Schiemann -- Rho GTPases and Their Activators, Guanine Nucleotide Exchange Factors (GEFs): Their Roles in Glioma -- Cell Invasion -- Bo Hu, Marc Symons, Bodour Salhia, Shannon P Fortin, Nhan L Tran, James Rutka, and Shi-Yuan Cheng -- Impact of Tumor Hypoxia, Src, and Met Signaling -- in the Dissemination of Tumor Cells -- Yao Dai, Wenyin Shi, Nikolett Molnar, and Dietmar Siemann -- Part II Homing and Colonization at Distant Sites -- Cellular and Molecular Biology of Cancer Cell Extravasation -- J Matthew Barnes and Michael D Henry Role of CXCL12 and CXCR4 in Tumor Biology -- and Metastasis -- Ramesh K Ganju, Yadwinder S Deol, and Mond W Nasser -- Transcription Factors Stat5a/b and Stat3 in Prostate -- Cancer Growth and Metastases -- Tuomas K Mirtti, Pooja Talati, and Marja T Nevalainen -- Survival and Growth of Prostate Cancer Cells in the Bone: Role of the Alpha-Receptor for Platelet-Derived Growth -- Factor in Supporting Early Metastatic Foci -- Qingxin Liu, Yun Zhang, Danielle Jernigan, and Alessandro Fatatis -- Androgen Receptor Regulation of Prostate Cancer -- Progression and Metastasis -- RS Schrecengost, MA Augello, and Karen E Knudsen -- Integrin Signaling in Angiogenesis and Metastatic -- Cancer Progression in the Brain -- Mihaela Lorger and Brunhilde Felding-Habermann -- Tumor and Host Determinants of Pulmonary -- Metastasis in Bladder Cancer -- Neveen Said and Dan Theodorescu -- The Influence of Metastatic Breast Cancer -- on the Bone Microenvironment -- Andrea M Mastro, Donna M Sosnoski, Venkatesh Krishnan, and Karen M Bussard. ISBN 9789400725577